ZFIN ID: ZDB-LAB-030925-2
Randall Peterson Lab
PI/Director: Peterson, Randall
Contact Person: Peterson, Randall
Email: randall.peterson@pharm.utah.edu
URL:
Address: College of Pharmacy University of Utah 30 South 2000 East Salt Lake City, UT 84112
Country: United States
Phone: 801-581-3402
Fax:
Line Designation: f


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 24 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS
Lam, Pui Ying Post-Doc Yuan, Shipeng Post-Doc Burger, Auxa


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Weeks, O., Bossé, G.D., Oderberg, I.M., Akle, S., Houvras, Y., Wrighton, P.J., LaBella, K., Iversen, I., Tavakoli, S., Adatto, I., Schwartz, A., Kloosterman, D., Tsomides, A., Charness, M.E., Peterson, R.T., Steinhauser, M.L., Fazeli, P.K., Goessling, W. (2020) Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood. The Journal of Clinical Investigation. 130(5):2252-2269
Lam, P.Y., Kutchukian, P., Anand, R., Imbriglio, J., Andrews, C., Padilla, H., Vohra, A., Lane, S., Parker, D.L., Taracido, I.C., Johns, D.G., Beerens, M., MacRae, C.A., Caldwell, J., Sorota, S., Asnani, A., Peterson, R.T. (2020) Cyp1 inhibition prevents doxorubicin-induced cardiomyopathy in a zebrafish heart failure model. Chembiochem : a European journal of chemical biology. 21(13):1905-1910
Nath, A.K., Ma, J., Chen, Z.Z., Li, Z., Vitery, M.D.C., Kelley, M.L., Peterson, R.T., Gerszten, R.E., Yeh, J.J. (2020) Genetic deletion of gpr27 alters acylcarnitine metabolism, insulin sensitivity, and glucose homeostasis in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34:1546-1557
Zhang, T., Trauger, S.A., Vidoudez, C., Doane, K.P., Pluimer, B.R., Peterson, R.T. (2019) Parallel Reaction Monitoring reveals structure-specific ceramide alterations in the zebrafish. Scientific Reports. 9:19939
Tu, J., Svatunek, D., Parvez, S., Eckvahl, H.J., Xu, M., Peterson, R.T., Houk, K.N., Franzini, R.M. (2019) Isonitrile-responsive and bioorthogonally removable tetrazine protecting groups. Chemical science. 11:169-179
Cassar, S., Adatto, I., Freeman, J.L., Gamse, J.T., Iturria, I., Lawrence, C., Muriana, A., Peterson, R., Van Cruchten, S., Zon, L. (2019) Use of Zebrafish in Drug Discovery Toxicology. Chemical Research in Toxicology. 33(1):95-118
McCarroll, M.N., Gendelev, L., Kinser, R., Taylor, J., Bruni, G., Myers-Turnbull, D., Helsell, C., Carbajal, A., Rinaldi, C., Kang, H.J., Gong, J.H., Sello, J.K., Tomita, S., Peterson, R.T., Keiser, M.J., Kokel, D. (2019) Zebrafish behavioural profiling identifies GABA and serotonin receptor ligands related to sedation and paradoxical excitation. Nature communications. 10:4078
Geng, Y., Peterson, R.T. (2019) The zebrafish subcortical social brain as a model for studying social behavior disorders. Disease models & mechanisms. 12(8)
Tsai, T.Y., Collins, S.R., Chan, C.K., Hadjitheodorou, A., Lam, P.Y., Lou, S.S., Yang, H.W., Jorgensen, J., Ellett, F., Irimia, D., Davidson, M.W., Fischer, R.S., Huttenlocher, A., Meyer, T., Ferrell, J.E., Theriot, J.A. (2019) Efficient Front-Rear Coupling in Neutrophil Chemotaxis by Dynamic Myosin II Localization. Developmental Cell. 49:189-205.e6
Lam, P.Y., Peterson, R.T. (2019) Developing zebrafish disease models for in vivo small molecule screens. Current Opinion in Chemical Biology. 50:37-44
Jordi, J., Guggiana-Nilo, D., Bolton, A.D., Prabha, S., Ballotti, K., Herrera, K., Rennekamp, A.J., Peterson, R.T., Lutz, T.A., Engert, F. (2018) High-throughput screening for selective appetite modulators: A multibehavioral and translational drug discovery strategy. Science advances. 4:eaav1966
Morningstar, J., Lee, J., Hendry-Hofer, T., Witeof, A., Lyle, L.T., Knipp, G., MacRae, C.A., Boss, G.R., Peterson, R.T., Davisson, V.J., Gerszten, R.E., Bebarta, V.S., Mahon, S., Brenner, M., Nath, A.K. (2018) Intramuscular administration of hexachloroplatinate reverses cyanide-induced metabolic derangements and counteracts severe cyanide poisoning.. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 1:81-92
Fischer, R.S., Lam, P.Y., Huttenlocher, A., Waterman, C.M. (2018) Filopodia and focal adhesions: An integrated system driving branching morphogenesis in neuronal pathfinding and angiogenesis. Developmental Biology. 451(1):86-95
Jin, Y.N., Schlueter, P.J., Jurisch-Yaksi, N., Lam, P.Y., Jin, S., Hwang, W.Y., Yeh, J.J., Yoshigi, M., Ong, S.E., Schenone, M., Hartigan, C.R., Carr, S.A., Peterson, R.T. (2018) Noncanonical translation via deadenylated 3' UTRs maintains primordial germ cells. Nature Chemical Biology. 14(9):844-852
Tu, J., Xu, M., Parvez, S., Peterson, R.T., Franzini, R.M. (2018) Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo. Journal of the American Chemical Society. 140(27):8410-8414
Basu, S., Jalodia, K., Ranjan, S., Yeh, J.J., Peterson, R.T., Sachidanandan, C. (2018) Small molecule inhibitors of NFkB reverse iron overload and hepcidin deregulation in a zebrafish model for Hereditary Hemochromatosis Type 3. ACS Chemical Biology. 13(8):2143-2152
Sips, P.Y., Shi, X., Musso, G., Nath, A.K., Zhao, Y., Nielson, J., Morningstar, J., Kelly, A.E., Mikell, B., Buys, E., Bebarta, V., Rutter, J., Davisson, V.J., Mahon, S., Brenner, M., Boss, G.R., Peterson, R.T., Gerszten, R.E., MacRae, C.A. (2018) Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning. PLoS One. 13:e0193889
Asnani, A., Zheng, B., Liu, Y., Wang, Y., Chen, H.H., Vohra, A., Chi, A., Cornella-Taracido, I., Wang, H., Johns, D.G., Sosnovik, D.E., Peterson, R.T. (2018) Highly potent visnagin derivatives inhibit Cyp1 and prevent doxorubicin cardiotoxicity. JCI insight. 3(1)
Bossé, G.D., Peterson, R.T. (2017) Development of an opioid self-administration assay to study drug seeking in zebrafish. Behavioural brain research. 335:158-166
Barros-Becker, F., Lam, P.Y., Fisher, R., Huttenlocher, A. (2017) Live imaging reveals distinct modes of neutrophil and macrophage migration within interstitial tissues. Journal of Cell Science. 130(22):3801-3808
Lam, P.Y., Mendu, S.K., Mills, R.W., Zheng, B., Padilla, H., Milan, D.J., Desai, B.N., Peterson, R.T. (2017) A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b. Scientific Reports. 7:11839
Wu, G., Nielson, J.R., Peterson, R.T., Winter, J.M. (2017) Bonnevillamides, Linear Heptapeptides Isolated from a Great Salt Lake-Derived Streptomyces sp. Marine drugs. 15(7)
Nath, A.K., Shi, X., Harrison, D.L., Morningstar, J.E., Mahon, S., Chan, A., Sips, P., Lee, J., MacRae, C.A., Boss, G.R., Brenner, M., Gerszten, R.E., Peterson, R.T. (2017) Cisplatin Analogs Confer Protection against Cyanide Poisoning. Cell chemical biology. 24(5):565-575.e4
Kimberly, W.T., O’Sullivan, J., Nath, A.K., Keyes, M., Yang, Q., Larson, M.G., Ramachandran, V., Peterson, R.T., Wang, T.J., Corey, .K, Gerszten, R.E. (2017) Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis. JCI insight. 2(9)
Noonan, H.R., Metelo, A.M., Kamei, C.N., Peterson, R.T., Drummond, I.A., Iliopoulos, O. (2016) Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma. Disease models & mechanisms. 9:873-884
Bruni, G., Rennekamp, A.J., Velenich, A., McCarroll, M., Gendelev, L., Fertsch, E., Taylor, J., Lakhani, P., Lensen, D., Evron, T., Lorello, P.J., Huang, X.P., Kolczewski, S., Carey, G., Caldarone, B.J., Prinssen, E., Roth, B.L., Keiser, M.J., Peterson, R.T., Kokel, D. (2016) Zebrafish behavioral profiling identifies multitarget antipsychotic-like compounds. Nature Chemical Biology. 12(7):559-66
Rennekamp, A.J., Huang, X.P., Wang, Y., Patel, S., Lorello, P.J., Cade, L., Gonzales, A.P., Yeh, J.J., Caldarone, B.J., Roth, B.L., Kokel, D., Peterson, R.T. (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nature Chemical Biology. 12(7):552-8
Vincent, W.J., Freisinger, C.M., Lam, P.Y., Huttenlocher, A., Sauer, J.D. (2016) Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish. Cellular Microbiology. 18(4):591-604
Brady, C.A., Rennekamp, A.J., Peterson, R.T. (2016) Chemical Screening in Zebrafish. Methods in molecular biology (Clifton, N.J.). 1451:3-16
Li, X., Rhee, D.K., Malhotra, R., Mayeur, C., Hurst, L.A., Ager, E., Shelton, G., Kramer, Y., McCulloh, D., Keefe, D., Bloch, K.D., Bloch, D.B., Peterson, R.T. (2016) Progesterone receptor membrane component-1 regulates hepcidin biosynthesis. The Journal of Clinical Investigation. 126(1):389-401
Palchaudhuri, R., Lambrecht, M.J., Botham, R.C., Partlow, K.C., van Ham, T.J., Putt, K.S., Nguyen, L.T., Kim, S.H., Peterson, R.T., Fan, T.M., Hergenrother, P.J. (2015) A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed. Cell Reports. 13:2027-36
Zhang, J., Yuan, S., Vasilyev, A., Amin Arnaout, M. (2015) The transcriptional coactivator Taz regulates proximodistal patterning of the pronephric tubule in zebrafish. Mechanisms of Development. 138 Pt 3:328-35
MacRae, C.A., Peterson, R.T. (2015) Zebrafish as tools for drug discovery. Nature reviews. Drug discovery. 14(10):721-31
Kleinstiver, B.P., Prew, M.S., Tsai, S.Q., Topkar, V.V., Nguyen, N.T., Zheng, Z., Gonzales, A.P., Li, Z., Peterson, R.T., Yeh, J.J., Aryee, M.J., Joung, J.K. (2015) Engineered CRISPR-Cas9 nucleases with altered PAM specificities. Nature. 523(7561):481-5
Vardy, E., Sassano, M.F., Rennekamp, A.J., Kroeze, W.K., Mosier, P.D., Westkaemper, R.B., Stevens, C.W., Katritch, V., Stevens, R.C., Peterson, R.T., Roth, B.L. (2015) Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides. Chemistry & Biology. 22:764-75
Martins Metelo, A., Noonan, H.R., Xiang, L., Jin, Y., Baker, R., Kamentsky, L., Zhang, Y., van Rooijen, E., Shin, J., Carpenter, A.E., Yeh, J.R., Peterson, R.T., Iliopoulos, O. (2015) Pharmacological HIF2α inhibition improves VHL disease–associated phenotypes in zebrafish model. J. Clin. Invest.. 125(5):1987-97
Nath, A.K., Ryu, J.H., Jin, Y.N., Roberts, L.D., Dejam, A., Gerszten, R.E., Peterson, R.T. (2015) PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation. Cell Reports. 10(5):694-701
Rennekamp, A.J., Peterson, R.T. (2015) 15 years of zebrafish chemical screening. Current Opinion in Chemical Biology. 24C:58-70
Lam, P.Y., Mangos, S., Green, J.M., Reiser, J., Huttenlocher, A. (2015) In vivo imaging and characterization of actin microridges. PLoS One. 10:e0115639
Liu, Y., Asnani, A., Zou, L., Bentley, V.L., Yu, M., Wang, Y., Dellaire, G., Sarkar, K.S., Dai, M., Chen, H.H., Sosnovik, D.E., Shin, J.T., Haber, D.A., Berman, J.N., Chao, W., Peterson, R.T. (2014) Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase. Science Translational Medicine. 6:266ra170
Tauzin, S., Starnes, T.W., Becker, F.B., Lam, P.Y., Huttenlocher, A. (2014) Redox and Src family kinase signaling control leukocyte wound attraction and neutrophil reverse migration. The Journal of cell biology. 207:589-98
Hwang, W.Y., Peterson, R.T., Yeh, J.R. (2014) Methods for targeted mutagenesis in zebrafish using TALENs. Methods (San Diego, Calif.). 69(1):76-84
Asnani, A., Peterson, R.T. (2014) The zebrafish as a tool to identify novel therapies for human cardiovascular disease. Disease models & mechanisms. 7:763-767
Burger, A., Vasilyev, A., Tomar, R., Selig, M.K., Nielsen, G.P., Peterson, R.T., Drummond, I.A., and Haber, D.A. (2014) A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12. Disease models & mechanisms. 7(7):907-13
van Ham, T.J., Brady, C.A., Kalicharan, R.D., Oosterhof, N., Kuipers, J., Veenstra-Algra, A., Sjollema, K.A., Peterson, R.T., Kampinga, H.H., Giepmans, B.N. (2014) Intravital correlated microscopy reveals differential macrophage and microglial dynamics during resolution of neuroinflammation. Disease models & mechanisms. 7:857-869
Walcott, B.P., and Peterson, R.T. (2014) Zebrafish models of cerebrovascular disease. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 34(4):571-577
Lam, P.Y., Fischer, R.S., Shin, W.D., Waterman, C.M., and Huttenlocher, A. (2014) Spinning disk confocal imaging of neutrophil migration in zebrafish. Methods in molecular biology (Clifton, N.J.). 1124:219-233
Lam, P.Y., Harvie, E.A., and Huttenlocher, A. (2013) Heat shock modulates neutrophil motility in zebrafish. PLoS One. 8(12):e84436
Lam, P.Y., Kamei, C.N., Mangos, S., Mudumana, S., Liu, Y., and Drummond, I.A. (2013) odd-skipped related 2 is required for fin chondrogenesis in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 242(11):1284-92
Goel, S., Gupta, N., Walcott, B.P., Snuderl, M., Kesler, C.T., Kirkpatrick, N.D., Heishi, T., Huang, Y., Martin, J.D., Ager, E., Samuel, R., Wang, S., Yazbek, J., Vakoc, B.J., Peterson, R.T., Padera, T.P., Duda, D.G., Fukumura, D., and Jain, R.K. (2013) Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression. Journal of the National Cancer Institute. 105(16):1188-1201
Hwang, W.Y., Fu, Y., Reyon, D., Maeder, M.L., Kaini, P., Sander, J.D., Joung, J.K., Peterson, R.T., and Yeh, J.R. (2013) Heritable and Precise Zebrafish Genome Editing Using a CRISPR-Cas System. PLoS One. 8(7):e68708
Zhang, Y., Wang, J., Wheat, J., Chen, X., Jin, S., Sadrzadeh, H., Fathi, A.T., Peterson, R.T., Kung, A.L., Sweetser, D.A., and Yeh, J.R. (2013) AML1-ETO mediates hematopoietic self-renewal and leukemogenesis through a COX/beta-catenin signaling pathway. Blood. 121(24):4906-16
Nath, A.K., Roberts, L.D., Liu, Y., Mahon, S.B., Kim, S., Ryu, J.H., Werdich, A., Januzzi, J.L., Boss, G.R., Rockwood, G.A., MacRae, C.A., Brenner, M., Gerszten, R.E., and Peterson, R.T. (2013) Chemical and metabolomic screens identify novel biomarkers and antidotes for cyanide exposure. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 27(5):1928-1938
Kokel, D., Cheung, C.Y., Mills, R., Coutinho-Budd, J., Huang, L., Setola, V., Sprague, J., Jin, S., Jin, Y.N., Huang, X.P., Bruni, G., Woolf, C.J., Roth, B.L., Hamblin, M.R., Zylka, M.J., Milan, D.J., and Peterson, R.T. (2013) Photochemical activation of TRPA1 channels in neurons and animals. Nature Chemical Biology. 9(4):257-263
Hwang, W.Y., Fu, Y., Reyon, D., Maeder, M.L., Tsai, S.Q., Sander, J.D., Peterson, R.T., Yeh, J.R., and Joung, J.K. (2013) Efficient genome editing in zebrafish using a CRISPR-Cas system. Nat. Biotechnol.. 31(3):227-229
Kokel, D., Dunn, T.W., Ahrens, M.B., Alshut, R., Cheung, C.Y., Saint-Amant, L., Bruni, G., Mateus, R., van Ham, T.J., Shiraki, T., Fukada, Y., Kojima, D., Yeh, J.R., Mikut, R., von Lintig, J., Engert, F., and Peterson, R.T. (2013) Identification of Nonvisual Photomotor Response Cells in the Vertebrate Hindbrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(9):3834-3843
Ishaq, O., Negri, J., Bray, M.A., Pacureanu, A., Peterson, R.T., and Wählby, C. (2013) Automated Quantification of Zebrafish Tail Deformation for High-Throughput Drug Screening. Proceedings IEEE International Symposium on Biomedical Imaging. 2013:902-905
Jin, S., Sarkar, K.S., Jin, Y.N., Liu, Y., Kokel, D., Van Ham, T.J., Roberts, L.D., Gerszten, R.E., MacRae, C.A., and Peterson, R.T. (2013) An In Vivo Zebrafish Screen Identifies Organophosphate Antidotes with Diverse Mechanisms of Action. Journal of Biomolecular Screening. 18(1):108-115
Peterson, R.T., and MacRae, C.A. (2013) Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish. Drug Discovery Today: Disease Models. 10(1):e37–e42
Yoo, S.K., Lam, P.Y., Eichelberg, M.R., Zasadil, L., Bement, W.M., and Huttenlocher, A. (2012) The role of microtubules in neutrophil polarity and migration in live zebrafish. Journal of Cell Science. 125(23):5702-5710
Lam, P.Y., Yoo, S.K., Green, J.M., and Huttenlocher, A. (2012) The SH2-domain-containing inositol 5-phosphatase (SHIP) limits neutrophil motility and wound recruitment in zebrafish. Journal of Cell Science. 125(21):4973-4978
Cade, L., Reyon, D., Hwang, W.Y., Tsai, S.Q., Patel, S., Khayter, C., Joung, J.K., Sander, J.D., Peterson, R.T., and Yeh, J.R. (2012) Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs. Nucleic acids research. 40(16):8001-8010
Kokel, D., Rennekamp, A.J., Shah, A.H., Liebel, U., and Peterson, R.T. (2012) Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology. Trends in Biotechnology. 30(8):421-425
van Ham, T.J., Kokel, D., and Peterson, R.T. (2012) Apoptotic Cells Are Cleared by Directional Migration and elmo1- Dependent Macrophage Engulfment. Current biology : CB. 22(9):830-836
Becker, J.R., Robinson, T.Y., Sachidanandan, C., Kelly, A.E., Coy, S., Peterson, R.T., and MacRae, C.A. (2012) In vivo natriuretic peptide reporter assay identifies chemical modifiers of hypertrophic cardiomyopathy signaling. Cardiovascular research. 93(3):463-470
Laggner, C., Kokel, D., Setola, V., Tolia, A., Lin, H., Irwin, J.J., Keiser, M.J., Cheung, C.Y., Minor, D.L., Roth, B.L., Peterson, R.T., and Shoichet, B.K. (2011) Chemical informatics and target identification in a zebrafish phenotypic screen. Nature Chemical Biology. 8(2):144-146
Sander, J.D., Cade, L., Khayter, C., Reyon, D., Peterson, R.T., Joung, J.K., and Yeh, J.R. (2011) Targeted gene disruption in somatic zebrafish cells using engineered TALENs. Nat. Biotechnol.. 29(8):697-698
Garkavtsev, I., Chauhan, V.P., Wong, H.K., Mukhopadhyay, A., Glicksman, M.A., Peterson, R.T., and Jain, R.K. (2011) Dehydro-α-lapachone, a plant product with antivascular activity. Proceedings of the National Academy of Sciences of the United States of America. 108(28):11596-601
Peal, D.S., Mills, R.W., Lynch, S.N., Mosley, J.M., Lim, E., Ellinor, P.T., January, C.T., Peterson, R.T., and Milan, D.J. (2011) Novel Chemical Suppressors of Long QT Syndrome Identified by an In Vivo Functional Screen. Circulation. 123(1):23-30
Groeneweg, J.W., White, Y.A., Kokel, D., Peterson, R.T., Zukerberg, L.R., Berin, I., Rueda, B.R., and Wood, A.W. (2011) cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish. Molecular reproduction and development. 78(1):22-32
Kokel, D., and Peterson, R.T. (2011) Using the zebrafish photomotor response for psychotropic drug screening. Methods in cell biology. 105:517-524
Peterson, R.T., and Fishman, M.C. (2011) Designing zebrafish chemical screens. Methods in cell biology. 105:525-541
Sander, J.D., Dahlborg, E.J., Goodwin, M.J., Cade, L., Zhang, F., Cifuentes, D., Curtin, S.J., Blackburn, J.S., Thibodeau-Beganny, S., Qi, Y., Pierick, C.J., Hoffman, E., Maeder, M.L., Khayter, C., Reyon, D., Dobbs, D., Langenau, D.M., Stupar, R.M., Giraldez, A.J., Voytas, D.F., Peterson, R.T., Yeh, J.R., Joung, J.K. (2011) Selection-free zinc-finger-nuclease engineering by context-dependent assembly (CoDA). Nature Methods. 8:67-9
Sander, J.D., Yeh, J.R., Peterson, R.T., and Joung, J.K. (2011) Engineering zinc finger nucleases for targeted mutagenesis of zebrafish. Methods in cell biology. 104:51-58
van Ham, T.J., Mapes, J., Kokel, D., and Peterson, R.T. (2010) Live imaging of apoptotic cells in zebrafish. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(11):4336-4342
Peal, D.S., Peterson, R.T., and Milan, D. (2010) Small Molecule Screening in Zebrafish. Journal of cardiovascular translational research. 3(5):454-460
Mangos, S., Lam, P.Y., Zhao, A., Liu, Y., Mudumana, S., Vasilyev, A., Liu, A., and Drummond, I.A. (2010) The ADPKD genes pkd1a/b and pkd2 regulate extracellular matrix formation. Disease models & mechanisms. 3(5-6):354-365
Das, B.C., McCartin, K., Liu, T.C., Peterson, R.T., and Evans, T. (2010) A forward chemical screen in zebrafish identifies a retinoic acid derivative with receptor specificity. PLoS One. 5(4):e10004
Ren, B., Deng, Y., Mukhopadhyay, A., Lanahan, A.A., Zhuang, Z.W., Moodie, K.L., Mulligan-Kehoe, M.J., Byzova, T.V., Peterson, R.T., and Simons, M. (2010) ERK1/2-Akt1 crosstalk regulates arteriogenesis in mice and zebrafish. J. Clin. Invest.. 120(4):1217-1228
Kokel, D., Bryan, J., Laggner, C., White, R., Cheung, C.Y., Mateus, R., Healey, D., Kim, S., Werdich, A.A., Haggarty, S.J., MacRae, C.A., Shoichet, B., and Peterson, R.T. (2010) Rapid behavior-based identification of neuroactive small molecules in the zebrafish. Nature Chemical Biology. 6(3):231-237
Zon, L.I., and Peterson, R. (2010) The new age of chemical screening in zebrafish. Zebrafish. 7(1):1
Rihel, J., Prober, D.A., Arvanites, A., Lam, K., Zimmerman, S., Jang, S., Haggarty, S.J., Kokel, D., Rubin, L.L., Peterson, R.T., and Schier, A.F. (2010) Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science (New York, N.Y.). 327(5963):348-351
Milan, D.J., Kim, A.M., Winterfield, J.R., Jones, I.L., Pfeufer, A., Sanna, S., Arking, D.E., Amsterdam, A.H., Sabeh, K.M., Mably, J.D., Rosenbaum, D.S., Peterson, R.T., Chakravarti, A., Kääb, S., Roden, D.M., and MacRae, C.A. (2009) Drug-Sensitized Zebrafish Screen Identifies Multiple Genes, Including GINS3, as Regulators of Myocardial Repolarization. Circulation. 120(7):553-559
Kitambi, S.S., McCulloch, K.J., Peterson, R.T., and Malicki, J.J. (2009) Small molecule screen for compounds that affect vascular development in the zebrafish retina. Mechanisms of Development. 126(5-6):464-477
Lam, P.Y., Webb, S.E., Leclerc, C., Moreau, M., and Miller, A.L. (2009) Inhibition of stored Ca release disrupts convergence-related cell movements in the lateral intermediate mesoderm resulting in abnormal positioning and morphology of the pronephric anlagen in intact zebrafish embryos. Development, growth & differentiation. 51(4):429-442
Yeh, J.R., Munson, K.M., Elagib, K.E., Goldfarb, A.N., Sweetser, D.A., and Peterson, R.T. (2009) Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation. Nature Chemical Biology. 5(4):236-243
Vasilyev, A., Liu, Y., Mudumana, S., Mangos, S., Lam, P.Y., Majumdar, A., Zhao, J., Poon, K.L., Kondrychyn, I., Korzh, V., and Drummond, I.A. (2009) Collective Cell Migration Drives Morphogenesis of the Kidney Nephron. PLoS Biology. 7(1):e9
Foley, J.E., Yeh, J.R., Maeder, M.L., Reyon, D., Sander, J.D., Peterson, R.T., and Joung, J.K. (2009) Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN). PLoS One. 4(2):e4348
Kokel, D., and Peterson, R.T. (2008) Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish. Briefings in functional genomics & proteomics. 7(6):483-490
Hong, C.C., Kume, T., and Peterson, R.T. (2008) Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification. Circulation research. 103(6):573-579
Mukhopadhyay, A., and Peterson, R.T. (2008) Deciphering arterial identity through gene expression, genetics, and chemical biology. Current opinion in hematology. 15(3):221-227
Peterson, R.T., Nass, R., Boyd, W.A., Freedman, J.H., Dong, K., and Narahashi, T. (2008) Use of non-mammalian alternative models for neurotoxicological study. Neurotoxicology. 29(3):545-554
Dayyani, F., Wang, J., Yeh, J.R., Ahn, E.Y., Tobey, E., Zhang, D.E., Bernstein, I.D., Peterson, R.T., and Sweetser, D.A. (2008) Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperate with AML1-ETO to affect myeloid cell proliferation and survival. Blood. 111(8):4338-4347
Yeh, J.R., Munson, K.M., Chao, Y.L., Peterson, Q.P., MacRae, C.A., and Peterson, R.T. (2008) AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression. Development (Cambridge, England). 135(2):401-410
Yu, P.B., Hong, C.C., Sachidanandan, C., Babitt, J.L., Deng, D.Y., Hoyng, S.A., Lin, H.Y., Bloch, K.D., and Peterson, R.T. (2008) Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism. Nature Chemical Biology. 4(1):33-41
Mathew, L.K., Sengupta, S., Kawakami, A., Andreasen, E.A., Löhr, C.V., Loynes, C.A., Renshaw, S.A., Peterson, R.T., and Tanguay, R.L. (2007) Unraveling tissue regeneration pathways using chemical genetics. The Journal of biological chemistry. 282(48):35202-35210
Smolen, G.A., Schott, B.J., Stewart, R.A., Diederichs, S., Muir, B., Provencher, H.L., Look, A.T., Sgroi, D.C., Peterson, R.T., and Haber, D.A. (2007) A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors. Genes & Development. 21(17):2131-2136
Peterson, R.T. (2006) A noncanonical path to mechanism of action. Chemistry & Biology. 13(9):924-926
Hong, C.C., Peterson, Q.P., Hong, J.Y., and Peterson, R.T. (2006) Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling. Current biology : CB. 16(13):1366-1372
Adams, D.S., Robinson, K.R., Fukumoto, T., Yuan, S., Albertson, R.C., Yelick, P., Kuo, L., McSweeney, M., and Levin, M. (2006) Early, H+-V-ATPase-dependent proton flux is necessary for consistent left-right patterning of non-mammalian vertebrates. Development (Cambridge, England). 133(9):1657-1671
Milan, D.J., Giokas, A.C., Serluca, F.C., Peterson, R.T., and MacRae, C.A. (2006) Notch1b and neuregulin are required for specification of central cardiac conduction tissue. Development (Cambridge, England). 133(6):1125-1132
Yuan, S., and Joseph, E.M. (2004) Small Heart Mutation Reveals Novel Roles of Na+/K+-ATPase in Maintaining Ventricular Cardiomyocyte Morphology and Viability in Zebrafish. Circulation research. 95(6):595-603
Peterson, R.T. (2004) Discovery of therapeutic targets by phenotype-based zebrafish screens. Drug discovery today. Technologies. 1:49-54
Shafizadeh, E., Peterson, R.T., and Lin, S. (2004) Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 138(3):245-249
Peterson, R.T., Shaw, S.Y., Peterson, T.A., Milan, D.J., Zhong, T.P., Schreiber, S.L., MacRae, C.A., and Fishman, M.C. (2004) Chemical suppression of a genetic mutation in a zebrafish model of aortic coarctation. Nat. Biotechnol.. 22(5):595-599
Peterson, R.T., and Fishman, M.C. (2004) Discovery and use of small molecules for probing biological processes in zebrafish. The Zebrafish: Cellular and Developmental Biology,2nd Ed. Methods Cell Biol.. 76:569-591
Milan, D.J., Peterson, T.A., Ruskin, J.N., Peterson, R.T., and MacRae, C.A. (2003) Drugs that induce repolarization abnormalities cause bradycardia in zebrafish. Circulation. 107(10):1355-1358
Peterson, R.T., Mably, J.D., Chen, J.-N., and Fishman, M.C. (2001) Convergence of distinct pathways to heart patterning reveals by the small molecule concentramide and the mutation heart-and-soul. Current biology : CB. 11:1481-1491
Peterson, R.T., Link, B.A., Dowling, J.E., and Schreiber, S.L. (2000) Small molecule developmental screens reveal the logic and timing of vertebrate development. Proceedings of the National Academy of Sciences of the United States of America. 97(24):12965-12969
Peterson, R.T. (2000) Roles for FRAP in phosphatase regulation, translation initiation, and vertebrate development. Ph.D. Thesis.