Lab

Nicolson Lab

Lab ID
ZDB-LAB-001113-2
PI / Directory
Nicolson, Teresa
Contact Person
Nicolson, Teresa
Email
tnicolso@stanford.edu
URL
http://nicolsonlab.stanford.edu/
Address
Country
United States
Phone
Fax
Line Designation
st
Genomic Features
Statement of Research Interest
Defects in sensory hair cells are thought to account for most forms of hereditary deafness. We aim to identify the components involved in hair-cell function by using a genetic approach. By screening over 7000 genomes (Tuebingen Screens I & II), we have identified a total of 24 genes that are required for balance and hearing in zebrafish. These circler mutants are analogous to the mouse shaker-waltzer mutants and can serve as alternative models for the study of human deafness. We are currently developing new ways of analyzing our mutants such stably expressing hair-cell specific markers, creating behavioral tests for auditory and vestibular function, and measuring physiological responses in hair cells and acousticolateralis nerves.
Lab Members
Gao, Yan Post-Doc Shipman, Anna Post-Doc Sun, Peng Post-Doc
Brodo-Abo, Sivan Research Staff
Zebrafish Publications of lab members