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Fig. 3

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ZDB-IMAGE-260710-4

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fosab

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Tsuji et al., 2026 - Neu1 deficiency is associated with reduced nicotine responsiveness and dopamine D3 receptor downregulation in zebrafish

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Fig. 3

Nicotine-induced neuronal activation in zebrafish brain. A Schematic of the sagittal section of the zebrafish brain. B–E Immunoreactivity of c-Fos in WT and neu1-KO zebrafish brains following Nco exposure, indicating neuronal activation patterns in multiple brain regions. WT and neu1-KO zebrafish were exposed to Nco (2.5 mg/L) for 15 min before brain collection. F–H Quantification of c-Fos fluorescence intensity in the hypothalamus, telencephalon, and diencephalon. n = 3. I Whole-brain c-fos mRNA expression following Nco exposure. n = 6. Fluorescence intensities and c-fos mRNA expression levels are shown relative to those of WT zebrafish without Nco exposure. Scale bars, 100 µm. Different letters indicate statistically significant differences between the groups

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Fish Physiol. Biochem.