IMAGE

Fig. 1

ID

ZDB-IMAGE-260601-1

Antibodies

Ab15-tuba

Publication

Bertrand et al., 2026 - ⍺TAT1-dependent microtubule acetylation is required for touch sensation in zebrafish but not for cilia-driven morphogenesis

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Figures for Bertrand et al., 2026

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Figure Caption

Fig. 1 ⍺TAT1 is not required for zebrafish development (A) Schematic of the 305-amino acid ⍺TAT1 protein showing the N-terminal catalytic domain. The atat1^sa9581 allele introduces a premature stop codon and the atat1^b1514 allele contains a frameshifting insertion in exon 1. Both alleles truncate the protein upstream of the catalytic domain. (B) Immunofluorescence of 5 dpf wild-type sibling and atat1 mutant larvae stained for ⍺-tub^K40Ac and total ⍺-tub. Scale bar, 1 mm. (C) Lateral views of wild-type sibling and atat1 mutant embryos at 48 hpf (left) and 3 mpf (right). Scale bar, 0.5 mm and 1 cm, respectively. (D) Wild-type sibling and atat1 mutant embryos injected with MO^⍺TAT1. Asterisk indicates oedema; arrows indicate body curvature (left). Percentage of embryos exhibiting malformations is quantified (right). Dots represent individual clutches; error bars indicate standard deviation. P values were calculated using the Mann-Whitney U test. Scale bar, 0.5 mm.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

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Reprinted from Developmental Biology, 535, Bertrand, S.G., Grimes, D.T., ⍺TAT1-dependent microtubule acetylation is required for touch sensation in zebrafish but not for cilia-driven morphogenesis, 124-132, Copyright (2026) with permission from Elsevier. Full text @ Dev. Biol.