Fig. 6.
- ID
- ZDB-IMAGE-260522-46
- Antibodies
- Publication
- Dockery et al., 2026 - Genes for 5'mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration
- All Figures
- Figures for Dockery et al., 2026
|
Fig. 6. An increased ratio of eif4e1c to canonical cap binding alleles improves heart regeneration. (A) Hearts, 7 days after amputation of the apex and after 3 days injection of EdU. CM are stained with α-Mef2c. (B) The single Δeif4ea mutants (green) and the Δeif4eb mutants (purple) have increased levels of CM proliferation (Mean: wildtype = 9.6%, Δeif4ea = 12.9%, Δeif4eb = 12.8%, Δeif4ea/Δeif4eb = 8.1%, ANOVA p < 0.0001, N = 48, 37, 40, 38). However, after a certain threshold, eif4e1c fully compensates since Δeif4ea/Δeif4ea double mutants (pink) regenerate like their wildtype (black) siblings. (C) Graph of fin regrowth 2 days post amputation in the respective mutants (Mean: wildtype = 244um, Δeif4ea/Δeif4eb = 270um, Δeif4ea = 194um, Δeif4eb = 183um, ANOVA p-value <0.0001, N = 50, 73, 41, 42). (D) Images of representative fins from the graph. Error bars representmean ± s.e.m. Scale bar = 100um. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Reprinted from Developmental Biology, 534, Dockery, R., Zevallos, M., McNulty, C., Zecchino, T., Ratermann, R., White, R., Kolonay, D., Baskin, K., Goldman, J.A., Genes for 5'mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration, 50-60, Copyright (2026) with permission from Elsevier. Full text @ Dev. Biol.