ZFIN Image: Gao et al., 2026, Figure 2.

Image

Figure Caption

Figure 2.

Integrated multi-omics reveals disrupted lipid metabolism in CERKL-deficient retina. (A) Volcano plot of differentially expressed metabolites (DEMs) in cerkl^−/− zebrafish compared with WT at 2 mpf. (B) Heatmap showing DEMs in WT and cerkl^−/− zebrafish. (C) Heatmap of TG and DAG levels in WT and cerkl^−/− zebrafish retina analyzed by metabolic. (D) TG levels in WT and cerkl^−/− zebrafish retina at 20 dpf and 2 mpf by TGs analysis kits. *, P < 0.05, ***, P < 0.001. (E) The fold change of PC in cerkl^−/− zebrafish retina at 2 months analyzed by metabolic. *, P < 0.05, **, P < 0.01, ***, P < 0.001. (F) Volcano plot of differentially expressed genes in cerkl^−/− zebrafish compared with WT at 2 months. (G) KEGG enriched lipid metabolism pathways (P < 0.05) are shown. (H) Representation of pathways altered in cerkl^−/− zebrafish based on transcriptomic and metabolomics of lipid data.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Invest. Ophthalmol. Vis. Sci.