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Figure 2.

ID: ZDB-IMAGE-260427-59
Publication: Gao et al., 2026 - PCYT1A Hypophosphorylation Underlies Retinal Lipid Dysregulation in CERKL Retinitis Pigmentosa and Is Therapeutically Reversed by Phosphatidylcholine
All Figures: Figures for Gao et al., 2026

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Figure 2.

Integrated multi-omics reveals disrupted lipid metabolism in CERKL-deficient retina. (A) Volcano plot of differentially expressed metabolites (DEMs) in cerkl^−/− zebrafish compared with WT at 2 mpf. (B) Heatmap showing DEMs in WT and cerkl^−/− zebrafish. (C) Heatmap of TG and DAG levels in WT and cerkl^−/− zebrafish retina analyzed by metabolic. (D) TG levels in WT and cerkl^−/− zebrafish retina at 20 dpf and 2 mpf by TGs analysis kits. *, P < 0.05, ***, P < 0.001. (E) The fold change of PC in cerkl^−/− zebrafish retina at 2 months analyzed by metabolic. *, P < 0.05, **, P < 0.01, ***, P < 0.001. (F) Volcano plot of differentially expressed genes in cerkl^−/− zebrafish compared with WT at 2 months. (G) KEGG enriched lipid metabolism pathways (P < 0.05) are shown. (H) Representation of pathways altered in cerkl^−/− zebrafish based on transcriptomic and metabolomics of lipid data.

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Acknowledgments

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