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Fig. 9

ID: ZDB-IMAGE-260403-37
Publication: Pérez-Escudero et al., 2026 - GPER1 reduces skin inflammation by inhibiting keratinocyte proliferation
All Figures: Figures for Pérez-Escudero et al., 2026

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Figure Caption

Fig. 9 Leukocytes infiltrating the epidermis of psoriasis-lesional skin are located in close proximity to proliferating keratinocytes.

a Representative images of skin biopsies from healthy subjects (HS) and psoriasis (PS) patients immunostained with a rabbit anti-human CD45 and a mouse anti-PCNA antibody, followed by the secondary antibodies donkey anti-rabbit IgG H&L Alexa Fluor® 488 and goat anti-mouse IgG H&L Alexa Fluor® 594. Sections were counterstained with DAPI and examined under a confocal microscope, Leica STELLARIS 8, and further processed with Leica software and ImageJ. The objective used was x63. Magnification at 63X (scale bar 50 µm). E epidermis, D dermis. b Analysis of the nearest neighbor assessing the Shortest Distance to Surface by Imaris; from surface 1 (green; CD45) to surface 2 (red; PCNA).

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