ZFIN Image: Gao et al., 2026, Figure 4

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Figure Caption

Figure 4

Correlation of GRGS with the immune microenvironment in colorectal cancer. (A) Heatmap showing ESTIMATE-derived Immune Score, Stromal Score and ESTIMATE Score alongside CIBERSORT-inferred proportions of 22 immune cell types in GRGS-High versus GRGS-Low groups. (B and C) Boxplots of and M2 macrophage abundances estimated by (B) CIBERSORT and (C) xCELL. (D) t-SNE plot of major immune and stromal cell clusters in the CRC_GSE146771_10X scRNA-seq dataset. (E) Violin plots comparing expression levels of GALNT7, MFNG, SLC35D1 and UST across identified cell lineages. (F–I) Gene-specific t-SNE overlays showing the spatial distribution of SLC35D1 (F), MFNG (G), GALNT7 (H) and UST (I) within the single-cell atlas. **, p < 0.01; ***, p < 0.001.

Acknowledgments

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