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Karchner et al., 2026 - Using fish models to understand the role of aryl hydrocarbon receptor (AHR)-interacting protein (AIP) in controlling sensitivity and resistance to dioxin-like compounds in vivo

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Fig. 6.

Wild-type (WT) and mutant (MUT) AIP transcripts in WT, HET, and HMZ mutant aip^wh239 larvae at 3 dpf (A, experiment 3a) and aip^wh86 larvae at 5 dpf (B, experiment 3b). Transcript numbers were assessed using RNA-seq data. Data represent the number of reads that overlap the deletion site in the aip gene, averaged over 4 replicate samples. The numbers include both maternal and zygotic transcripts. Results show that HMZ mutant embryos have some WT maternal transcripts at 3 and 5 dpf. Mutant transcripts appear to be rapidly degraded, suggesting nonsense-mediated decay. Abbreviations used: WT: Wild-type; HET: Heterozygous; HMZ: Homozygous.

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Toxicol. Sci.