ZFIN Image: Dahlgren et al., 2026, Figure 4

Image

Figure Caption

Figure 4 Clinical phenotyping and analysis of platelets from affected horses.

(A) TBTs using horses that were Ref/Ref or Alt/Alt for the SEL1L c.1810A>G p.Ile604Val variant found no significant difference between genotypes by 2-tailed Student’s t test. n = 10 Ref/Ref and 3 Alt/Alt. (B) SEL1L (red) localization in relation to P selectin (green) in (top) resting permeabilized platelets and (bottom) thrombin-activated platelet surface of horses that are Ref/Ref for SEL1L c.1810A>G p.Ile604Val. SEL1L did not localize to the surface in resting permeabilized platelets (top) but did localize to the surface in thrombin-activated platelets (bottom). n = 2. Original magnification, ×100. (C) Collagen spreading assay comparing median platelet area to genotype. There was a substantial difference between homozygous Ref and Alt genotypes. n = 11 Ref/Ref, 5 Ref/Alt, and 2 Alt/Alt.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Journal of Clin. Invest.