IMAGE

Figure S1.

ID
ZDB-IMAGE-260131-108
Publication
Valagussa et al., 2025 - A heterozygous USB1 variant linked to immunodeficiency
All Figures
Figures for Valagussa et al., 2025
Image
Figure Caption

Figure S1.

Structural analysis of the P44L mutation in the USB1 protein. (A) The de novo variant is situated within the only modeled ternary structure of the N-terminal domain, which is predicted to be predominantly disordered (AF-Q9BQ65-F1-v4, AlphaFold Protein Structure Database [10, 11, 12]). (B) Comparison of the local structural environment around residue 44 in the wild-type (USB1WT) and mutant (USB1P44L) proteins. The model was visualized using the PyMOL Molecular Graphics System (Version 3.1.0 Schrödinger, LLC).

Acknowledgments
This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J Hum Immun
Your Input Welcome
We welcome your input and comments. Please use this form to report issues or recommend updates to the information in ZFIN. We appreciate as much detail as possible and references as appropriate. We will review your comments promptly.
Please check the highlighted fields and try again.
Thank you for submitting comments. Your input has been emailed to ZFIN curators who may contact you if additional information is required.
Oops. Something went wrong. Please try again later.