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Ahn et al., 2025 - The role of AP2M1 in oncofetal characteristics: integrative in silico, in vitro, and in vivo analyses using zebrafish models

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Fig. 3

ap2m1a is crucial for hepatocyte proliferation in zebrafish embryo model. A The structure of human AP2M1 (top) and zebrafish ap2m1a (bottom). The black arrow indicates structural differences between the two. B The amino acid sequence of human AP2M1 and zebrafish ap2m1a. The MHD (Mu homology domain) was represented by red box. C The expression of ap2m1a mRNA was detected by RT-qPCR in various concentration of ap2m1a-MO. Data were quantified and expressed as the mean ± SEM of 3 independent experiments. ***p < 0.001 vs. value in the negative control. D The expression of fabp10a mRNA was detected by RT-PCR in uninjected embryos and ap2m1a-MO 2.5 ng/nl injected embryos. Data were quantified and expressed as the mean ± SEM of 3 independent experiments. ***p < 0.001 vs. value in the negative control. E Quantitative analysis of the sizes of 27 uninjected embryos and 26 ap2m1a-MO 2.5 ng/nl injected embryos. fabp10a expression in those embryos was detected by WISH. The black arrow demonstrates zebrafish hepatocytes. Data were quantified and expressed as the mean ± SEM of each embryo. ****p < 0.0001 vs. value in the negative control

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This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Eur J Med Res