ZFIN Image: Mensching et al., 2025, Fig. 3.

Image

Figure Caption

Fig. 3.

Smc3 protein depletion protects lateral line neuromasts from neomycin cytotoxicity. (A) Representative images of lateral line neuromasts in SC-KD larvae and Smc3-KD larvae at 5 dpf with and without neomycin treatment and stained with 2-[4-(Dimethylamino)styryl]-1-ethylpyridinium iodide (DASPEI). Scale bars: 100 µm. (B) Quantification of neuromast survival after neomycin treatment for each injection type. Neuromast survival was calculated as the ratio of observed neuromasts in each neomycin-treated embryo to the average number of neuromasts visible in control-treated embryos of the same injection type (e.g. SC-KD or Smc3-KD). By this method, ratios greater than 1 may occur if the number of observed neuromasts in a neomycin-treated embryo exceeds the average number of neuromasts observed in the relevant control-treated embryos. Student's t-test, ****P<0.0001, SC-KD n=40, Smc3-KD n=36.

Figure Data

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Biol. Open