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FIGURE 6

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Publication: Chen et al., 2025 - Ddx3xa mutations drive cardiac defects in a zebrafish model via dysregulation of wnt/β-catenin signaling
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FIGURE 6

Transcriptomic alterations in ddx3xa^−/− zebrafish at 72 hpf. (A) Principal component analysis (PCA) of the transcriptome revealed clear separation between WT and ddx3xa^−/− groups along PC1, which accounted for 97.6% of the total variance (PC2: 1.5%). Sample distribution: wild-type (WT) controls (red) versus ddx3xa^−/− mutants (blue). (B) Volcano plot of differentially expressed genes (DEGs): downregulated (blue), nonsignificant (gray), upregulated (red). (C) Hierarchical clustering heatmap: rows represent genes, columns represent samples. Expression levels scaled from high (red) to low (blue). (D) KEGG pathway enrichment analysis.

Acknowledgments

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