Figure 1

Figure 1 Fish with different telomerase genotypes regenerate with different efficiency.

(A) Experimental design of a regeneration assay with a single amputation (black dotted tracing) and growth monitoring (arrowhead and line), at three different ages of life (4, 8, and 11 month old) in tert+/+, tert+/−, and tert−/− zebrafish for 24 days. The caudal peduncle is indicated in a blue dotted line. (B) Caudal fin regeneration slope of 8-month-old zebrafish from the three genotypes. The arrows indicate 100% regeneration of the tail fin. n = 3 experiments with two biological replicates each. Data were mean + s.e.m. (C) Days post amputation to reach 50% of the caudal fin regeneration at three different ages and from the three telomerase genotypes. n = 3 experiments. Each dot represents a biological replicate. Data were mean + standard deviation ***P < 0.001 and ****P < 0.0001 for two-way ANOVA plus Dunnett’s post hoc test. dpa days post amputation. When exact p values are not indicated is because GraphPad Prism software does not show it. Source data are available online for this figure.