ZFIN Image: An et al., 2025, Fig. 5

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Figure Caption

Fig. 5

SMIM45-107aa activated the AKT signaling pathway by modulating MGST1 and MTDH. (A) Proteomics analysis was employed to identify differentially expressed genes in SK-Hep1 cells between SMIM45-107aa-ovexression or knockdown groups and the control group (log₂ fold < 1.2, p < 0.5). (B) Venn diagram showing the overlap of differentially expressed proteins identified in SMIM45-107aa-overexpression and SMIM45-107aa-knockdown groups. (C) The GO analysis of the 42 differentially expressed genes. (D) The pathway enrichment analysis of the 42 differentially expressed genes. (E–F) Western blot analysis of indicated proteins in SMIM45-107aa-overexpression SK-Hep1 and SNU449 cells

Acknowledgments

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