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Fig. 1 Schematic view of genes. Of the 38 genome-wide significant loci, 4 are potentially novel, and 34 are known from previous GWASs. Of the potentially novel genes, 2 have supportive evidence from recent GWAS meta-analyses.38,39 Six of the previously known genes were functionally validated in this study using a zebrafish model of blood clotting with 3 genes showing supportive evidence (significant validation) as the causal gene for modification of VTE in humans.
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