Fig. 1

Fig. 1 An F0-based MMEJ screening identified erk1 and mek1 as therapeutic modifiers of ttntv DCM. (A) Quantification of the ejection fraction in adult F0 zebrafish at 3 months via high-frequency echocardiography. (n ≥8 per group). (B) Quantification of representative knock out scores in F0 fish at 3 months. (n ≥6 per group) (C) Quantification of ejection fraction in F1 zebrafish at 3 months via high-frequency echocardiography. (n ≥ 8 per group). (D) Evaluation of nppb gene transcripts expression by quantitative RT-PCR in hearts from 3 months adult zebrafish. n ≥4 per group. One-way ANOVA was used to compare multiple groups for each mutation. Data are presented as mean ± SEM, *p < 0.05, **p < 0.01. WT, wild type, ns, non-significant.