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Fig. 4 Inhibition of Hdac11 induces apoptosis through pdcd6 in ZF4 cells. (a) The mRNA level of pdcd6 was detected after ZF4 cells were transfected with 100 pmol sipdcd6 or siNC for 24 h. (b, c) ZF4 cells were pre-treated with 1 µM JB3-22 for 2 h, or transfected with 100 pmol sipdcd6, or siNC for 8 h, then cultured at 28 °C–18 °C (cold stress) for 24 h, respectively. Apoptosis was detected by Annexin V-FITC/PI staining. Data are represented as mean ± SD of three independent experiments, and P values were calculated using Student’s t-test (n.s. P > 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001).
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