ZFIN Image: Sandler et al., 2025, Fig. 5

Image

Figure Caption

Fig. 5 Integrating ear scRNA-seq to build a hair cell differentiation GRN.a–e UMAPs of integrated scRNA-seq, showing sibling lateral line, prdm1a-/- lateral line, embryo otic subset, ear scRNA-seq, and complete integration, respectively. f Integrated ear prdm1a-/- hair cell cluster with cells color coded by cell type from the ear scRNA-seq annotation5. prdm1a-/- hair cells are in gray. g Heatmap of mature hair cell genes of the triple integrated scRNA-seq data set, divided into prdm1a-/- lateral line cells, ear hair cells of the embryo otic subset and ear scRNA-seq data sets. h GRN of zebrafish lateral line hair cell specification and development. i GRN of zebrafish ear hair cell specification and development. j GRN of mouse inner hair cell specification and development. k GRN of mouse outer hair cell specification and development. Numbers in brackets indicate citations for the individual interactions.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Nat. Commun.