ZFIN Image: Wheelan et al., 2025, Fig. 2.

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Fig. 2.

Survival Analysis. Kaplan–Meier survival curve comparing percent survival among three transgenic zebrafish cohorts: EGFP (n=37), wtICER (n=48), and S35-41A-ICER (n=40) over a 104-week observation period. Survival curves were generated using the Kaplan–Meier estimator, with survival differences assessed using the log-rank test (P<0.05). Fish expressing wtICER displayed significantly reduced survival compared to the EGFP control via pair-wise t-test, correlating with more aggressive tumor histology observed in Fig. 3. In contrast, fish expressing the S35-41A-ICER mutant showed improved survival compared to wtICER (P<0.05), consistent with reduced tumorigenesis.

Acknowledgments

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