ZFIN Image: Mo et al., 2025, Figure 4.

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Figure Caption

Figure 4.

PMMEXOs inhibits the expression of melanin-related proteins and genes. (A) Immunofluorescence staining of MITF, TYR, TYRP-1 and TRP-2 proteins during melanin production. After incubation for 24 h, fluorescent of MITF, TYR, TYRP-1 and TRP-2 proteins, nuclei stained with DAPI. Scale bars = 200 μm. Quantitative fluorescence intensity analysis of MITF (B), TYR (C), TYRP-1 (D), TRP-2 (E) proteins. n = 5. The mRNA expression levels of MITF (F), TYR (G), TYRP-1 (H) and TRP-2 (I) in PMMEXOs treated cells were detected by RT-qPCR (n = 3). Data were expressed as mean ± SD, and one-way analysis of variance was used for statistical significance. n. s. no significant difference observed between groups. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 compared with α-MSH model group, ####P < 0.0001 compared with the blank group.

Acknowledgments

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