ZFIN Image: Shen et al., 2025, Figure 1

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Figure 1

Cross-species bioinformatics identified conserved aging signatures in cerebrovascular endothelial cells. (A) Volcano plots showing the differentially expressed genes in mid- and old-aged human cerebrovascular endothelial cells; (B) GO analysis of down-regulated genes in aged human cerebrovascular endothelial cells; (C) GO analysis of up-regulated genes in aged human cerebrovascular endothelial cells; (D) KEGG analysis of down-regulated genes in aged human cerebrovascular endothelial cells; (E) Volcano plots showing the differentially expressed genes in mid- and old-aged mouse cerebrovascular endothelial cells; (F) Wayne diagrams showing the overlapped up and down-regulated genes in aged human and mouse cerebrovascular endothelial cells; (G) Expression of rps20 in human and mouse cerebrovascular endothelial cells in mid-aged and old-aged adults; (H–J) Genes and signaling pathways involved in the rps20 participated GO terms.

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