Fig. 10

Fig. 10

Genes associated with cardio-metabolic diseases. Cardio-metabolic disease GWAS genes ranked by normalized row sum in the age-related transcriptome hypergraphs of control and GRB10 knockdown zebrafish. Six genes out of 29 differentially expressed genes were present in both the SC and KD were shown to be related to cardiometabolic health. A) The impact of these genes on hypergraph connectivity and, B) higher order interactions in the transcriptome hypergraph were measured and ranked using a normalized ranking score, higher value indicates greater number of interactions in the transcriptome and implies greater impact on function by increased cross talk between biological pathways. C) Human Genome Wide Association Study (GWAS) relationships identified by phenome wide association using the fourteen human orthologous genes present in overlap between SC and KD hypergraphs. Identified using PHEWAS catalogue. D) Interactome model of the fourteen human orthologous genes present in overlap between SC and KD hypergraphs, demonstrating coherency and implying co-ordination