ZFIN Image: Sweeney et al., 2025, Fig. 1

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Figure Caption

Fig. 1

Process of CREB3L3 nuclear localization. 1: In the inactive state, CREB3L3 is anchored to the membrane of the endoplasmic reticulum (ER). 2: An unknown signal induces the release of the tethered protein from the ER membrane, and CREB3L3 is transported to the Golgi. 3: Proteases (S1P, S2P) cleave the transmembrane domain of the protein in the Golgi. 4: Upon cleavage, the DNA-binding domain of the protein can be trafficked to the nucleus. 5: CREB3L3 regulates expression of key lipid metabolism and apoprotein genes by binding to promoter regions and altering transcriptional processes in the nucleus. CREB3L3, cAMP-responsive element-binding protein 3–like 3.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Lipid Res.