ZFIN Image: Evans et al., 2025, Fig. 6

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Figure Caption

Fig. 6

The coordination of age associated genes is altered by grb10a KD, as assessed by hypergraph analysis (A) hypergraphs form clusters of genes with higher order interactions between them; this allows us to refine groups of causally associated elements from a broader set of targets. (B) hypergraph analysis of the identified age-associated genes formed three such clusters of genes in SC zebrafish, corresponding to [1] 5 dpf, [2] 10–15 dpf, and [3] 20–30 dpf. (C) Two clusters were defined in the KD data, corresponding to [1] 5–15 dpf and [2] 20–30 dpf. (D) and (E) Violin plots of connectivity (left) and entropy (right) in the 20–30 dpf cluster. The KD transcriptome was more connected with higher entropy compared to SC, suggesting a more diverse set of connections are made by age associated genes (Wilcoxon Rank sum **** p < 0.0001)

Acknowledgments

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