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Fig. 11 The mechanism of action of 8e. (A–G) The expression of identified differentially expressed proteins (Pfdn1, Ace, Dao, Vldlr, Yes1, Arg1, and Pdk1) closely related to the progression of AD. (H) The expressions of pfdn1 and VLDLR in cerebral cortex were determined by qPCR. (I) The expressions of pfdn1 and VLDLR in cerebral cortex were detected by Western blot. (J) The schematic diagram of the possible mechanism of action for compound 8e. Values are presented as mean ± SD from three independent experiments. #P < 0.05, ##P < 0.01, ###P < 0.001 vs. control group; ∗P < 0.05, ∗∗∗P < 0.001, ∗∗∗∗P < 0.0001 vs. model group.