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Fig. 8 In vivo effects of 8e in APP/PS1 mice. (A) The learning abilities of the 6-month-old APP/PS1 mice were assessed using the MWM. (B) The escape latency changes were recorded in various groups. (C) Weight changes were recorded in various experimental groups. In the MWM assay were recorded. (D–I) The effects of 8e to evaluate spatial memory and long-term memory by observing and recording escape platform retention times, number of escape platform entries, escape platform distance, effective zone movement times, number of effective zone entries and effective zone movement distance. (J) Escape latency trace in various group. (K) Effective zone movement distance trace in various group. Values are presented as mean ± SD from three independent experiments. ###P < 0.001 vs. wild-type C57BL/6 mice group; ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001 vs. APP/PS1 mice group.