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Fig. 7 Effects of 8e on scopolamine-induced mice dysmnesia using the step-down passive avoidance task. (A) The step-down lantancy changes in various group. (B) Error times changes in various group. (C, D) Neuronal apoptosis in the hippocampus was conducted and analyzed using TUNEL staining. (E, F) The cumulative transport of 8e on the AP-BL/BL-AP side was evaluated. (G, H) The permeability of compound 8e was evaluated using the Papp values. (I) The tissue distribution of compound 8e in SD mice (220–250 g) following oral administration at a dose of 25 mg/kg at various time points. Values are presented as mean ± SD from three independent experiments. Values are presented as mean ± SD from three independent experiments. ##P < 0.01, ###P < 0.001 vs. control group; ∗∗P < 0.01, ∗∗∗P < 0.001 vs. model group.