ZFIN Image: Wieloch et al., 2025, Fig. 1

Image

Figure Caption

Fig. 1 Schematic comparison of in vivo/in vitro developmental timeline. Summary of the early developmental processes of mice embryos in vivo (E3.5–7) and the matching developmental stage of in vitro 3D embryoids, according to [13]. The range of developmental potential of each model (blastoid, embryoid or gastruloid) to cover the developmental processes depicted in gray boxes at the top of the time-lines is indicated by the start and end points of the colored bars. AVE: Anterior visceral endoderm; A-P: Anterior–Posterior; DE: Definitive endoderm; DIV: day in vitro; DVE: Distal visceral endoderm; EmVE: Embryonic visceral endoderm; EMT: Epithelial–mesenchymal transition; EPI: Epiblast; ExE: Extra-embryonic ectoderm; ExVE: Extra-embryonic visercal endoderm; PrE: Primitive endoderm; TE: Trophectoderm.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image.

Reprinted from Reproductive toxicology (Elmsford, N.Y.), , Wieloch, J., Blanco, J., Zordick, C., Ohnesorge, N., Schneider, M.R., Barenys, M., Knöspel, F., In vitro embryolethality testing during the peri-implantation stage using 3D mouse embryoids: comparison with 2D mouse cell cultures and the zebrafish embryo model, 108941108941, Copyright (2025) with permission from Elsevier. Full text @ Reprod. Toxicol.