ZFIN Image: Chang et al., 2025, Fig. 5

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Figure Caption

Fig. 5 Effects of Tl exposure combined with IXA4 or TUDCA treatment on the transcriptome of zebrafish embryos.(A) Heatmap showing the expression patterns of differentially expressed genes (DEGs) among the control, Tl, Tl+IXA4, and Tl+TUDCA treatment groups, represented as Z-scores. (B) Bar graph illustrating the number of DEGs compared to the control group, including upregulated genes (orange) and downregulated genes (blue) for the Tl, Tl+IXA4, and Tl+TUDCA groups. Volcano plots displaying the changes in gene expression: (C) Tl versus control, (D) Tl+IXA4 versus control, and (E) Tl+TUDCA versus control. Red dots represent significant DEGs, with cut off value that absolute log2 fold change ≥ 1 and adjusted p-value < 0.05. Results are based on RNA-seq analysis, with an exposure period from 6 to 48 hpf and a sample size of n = 3 per group.

Acknowledgments

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