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Fig. 5 Defining conserved p53-upregulated genes in zebrafish and mouse (A) Venn graphs representing p53-upregulated DEGs in mouse p53+/+ at 1 and 3 hpi. The cut-off is fold change ≥1.5 and q < 0.05. (B) Venn graph showing 1,617 p53-induced genes in mouse p53+/+ between 1 and 3 hpi. (C) The diagram showing the analysis on mouse orthologs of p53-upregulated DEGs in pnp−/− zebrafish embryos at 1 and 3 hpi. For 264 p53-upregulated DEGs defined in zebrafish at 1 or 3 hpi, 247 of them are with mouse orthologs. Among them, 226 genes have one ortholog, and 21 of them are with multiple orthologs. 12 did not define orthologs in mouse. Five of them are non-coding genes. And 247 zebrafish p53-upregulated DEGs are corresponding to 323 mouse orthologs and 1,804 mouse paralogs. Among them, 232 genes are upregulated in mouse WT but not in p53−/− treated versus untreated. Finally, defining 137 zebrafish p53-induced DEGs are also conserved upregulated by p53 in mouse.