ZFIN Image: Abgueguen et al., 2025, Figure 6.

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Figure Caption

Figure 6. Sephin1 increases eIF2α phosphorylation level and reduces TDP-43 in TIF from spinal cord motor neurons of SOD1^G93A female mice at 20 wk of age.

(A) Representative pictures of immunoblot of eIF2α phosphorylated and eIF2α proteins in spinal cord of 20-wk-old SOD1^G93A mice treated with vehicle, Sephin1 at 4 or 8 mg/kg per day. (B) eIF2α phosphorylation level in the spinal cord of 20-wk-old SOD1^G93A mice treated with vehicle, Sephin1 at 4 or 8 mg/kg per day. (C) Representative images of immunoblot of hSOD1 protein in spinal cord of 20-wk-old SOD1^G93A mice treated with vehicle, Sephin1 at 4 or 8 mg/kg per day. (D) hSOD1 protein level in spinal cord of 20-wk-old SOD1^G93A mice treated with vehicle, Sephin1 at 4 or 8 mg/kg per day. (E) Representative picture of TDP-43 immunoblot of TIF from spinal cord of 20-wk-old SOD1^G93A mice treated with vehicle, Sephin1 at 4 or 8 mg/kg per day. (F) TDP-43 level in TIF from spinal cord of 20-wk-old SOD1^G93A mice treated with vehicle, Sephin1 at 4 or 8 mg/kg per day. *P < 0.05 versus vehicle Kruskal-Wallis test followed by Dunn’s multiple comparison test; mean ± SEM n = 3–5 mice per condition.

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