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Fig. 6 APOA4 downregulation caused the potent toxicity of SSe compared to SeNP. (A, B) Volcano plot visualizing the fold change of DEGs in SeNP vs Control and SSe vs Control of murine livers. (C, E) GO enrichment analysis of SeNP vs Control and SSe vs Control of murine livers. (D, F) Upset plot showing the shared DEGs in GO enrichment pathways of SeNP vs Control and SSe vs Control of murine livers. (G) GO enrichment network plot of DEGs of SSe vs Control of murine livers. (H) APOA4 mRNA expression of murine livers. (I) APOA4 protein expression of murine livers by Western blot. (J) Quantitative analysis of APOA4 protein expression of murine livers in (I). (K) GPX4 and APOA4 protein expression of BNL CL.2 cell by Western blot. (L, M) Quantitative analysis of protein expression in (K). The data represent the mean value ± SD. Different capital letters indicate significant differences among groups (p < 0.05). * p < 0.05 vs Control, ** p < 0.01 vs Control.