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Figure Caption
Fig. 1 Schematic of the high-throughput drug screening in experimental EPP zebrafish. A total of 2560 compounds were multiplexed into 640 test wells. Positive hits were identified on the basis of significant reduction of the PP-IX (red) signal in EPP zebrafish livers (n ≥10 fish larvae; N ≥4 experiments). Funnel cartoons represent the progressive flow in the number of active compounds toward a validated optimal hit/compound for further investigation. Note the decrease in red liver fluorescence (right upper part of the schematic).
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Full text @ Cell Mol Gastroenterol Hepatol