Figure 3

Figure 3

Regorafenib and infigratinib treatment inhibits RMS xenograft tumour growth. (A), Xenografts generated from the 7 RMS cell lines were treated with 0.1 µM regorafenib and infigratinib for 66 hours. Bar graphs of tumour area for treated xenografts relative to the average vehicle treated tumour area for each cell line. Dotted line indicates level of relative tumour area for vehicle treated xenografts (1.0 = 100% for each cell line). (B), RMS cell lines were treated in vitro in 2D with regorafenib and infigratinib at a range of concentrations (0.1-10 µM) for 7 days (as described in Supplementary Figure 6a) with the drug concentration inducing a 50% reduction in maximum cell surface, relative to vehicle treated (GI50) calculated and shown in the bar graphs. Data are presented as mean values +/- SEM. n = number of xenografts.