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Fig. 6

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ZDB-IMAGE-250526-65
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Figures for Shi et al., 2025
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Figure Caption

Fig. 6 Gastrodin treatment effectively enhances remyelination in EAE mice.

a Schematic depicting EAE model and gastrodin treatment (gastrodin setting, 100 mg/kg ip). IT: initial treatment, PT: Peak treatment. b, c Clinical score in EAE mice treated at 1 dpi (left) or treated at disease peak (right) with gastrodin or vehicle (n = 6–10 mice). d LFB staining of spinal cord sections at 30 dpi (left) and quantification of the demyelinated white matter’s percentage (right, n = 3 mice). Black boxes zoom in are shown below. e Representative images of MBP (green) immunofluorescence in spinal cord sections at 30 dpi (left) and quantification of MBP+ area’s percentage (right, n = 3 mice). f Representative images of CC1 (red) and Sox10 (green) immunofluorescence around lesions at 30 dpi (left), and quantification of CC1+Sox10+ cells/mm2 (right, n = 3 mice). White boxes zoom in are shown below. Data are represented as mean ± SEM, Mann–Whitney U in b and c, one-way ANOVA with Tukey in df.

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