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Fig. 3 Differentially expressed genes (DEGs) in H1048-ER cells and H1048 cells. A Volcano map of DEGs. Red, gray, and blue dots represent DEGs with upregulated, unchanged, and downregulated expression, respectively. B Clustering heatmap of DEGs. C Bubble map after enrichment analysis using the GO database. The larger the circle, the greater the number of DEGs enriched to that term. The closer the circle is to the top of the image, the greater the significance of the term. D Bubble map after enrichment analysis using the KEGG database. The larger the circle, the greater the number of DEGs enriched to that term. The closer the circle is to the top of the image, the greater the significance of the term. E Bubble map after enrichment analysis using the Reactome database. The larger the circle, the greater the number of DEGs enriched in this pathway. The closer the circle is to the top of the image, the more significant the pathway becomes. F Venn diagram of enrichment using GO, KEGG, and Reactome database