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Fig. 6 Impact of the zygosity of the floxed allele on recombination efficiency. a Schematic representation of the heterozygous (HET) versus homozygous (HOM) floxed alleles. b and c Male homozygous and heterozygous floxed mouse strains with either wildtype loxP (b) or mutant loxP (c)—R26-0.8 kb, R26-2.25 kb, Rhbdf1-2.9 kb, R26-6.9 kb, and R26-8 kb—were bred with female Ella-cre or Sox2-cre mice. The F1 offspring were then genotyped using PCR and categorized as recombined, still floxed, or mosaic. Note that the percentages were rounded to the nearest whole percent.
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