FIGURE 1

FIGURE 1

Differentially expressed SASP factors after acute light damage. Bulk RNAseq was performed on whole zebrafish retinas after acute light damage and compared to undamaged controls. (A–G) Volcano plots depicting up- and downregulated SASP factors and senescence markers at the indicated times post damage. Dashed lines represent values with a |log₂FC| > 2 and p-values <10⁻⁶. Top significantly upregulated factors are labeled for each time point. (H) Heatmap showing enrichment of SASP factors at the indicated times post light damage. SASP factors and senescence markers were included in the heatmap if they had a log₂FC > 3 with p-values <10⁻⁶ for at least one time point; bolded genes are part of the SASP-related Regeneration Factors (SRRFs).