ZFIN Image: Garcia-Peiro et al., 2025, Fig. 5

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Figure Caption

Fig. 5 a) Pt-mediated conversion of prodrug Pro-SN38 into cytotoxic SN38 (created with BioRender). b) Cell viability assay in HCT116 colon carcinoma cells under different treatment conditions using dPt-2. c) Cell viability assay in HCT116 colon carcinoma cells under different treatment conditions using PEG-dPt-2. [Prodrug/drug]=10–30–100 nM. Cells were treated with dPt-2 (80 μg/mL) or PEG-dPt-2 (80 μg/mL) followed by the prodrug. PrestoBlue viability assay was performed 5 days after treatment. Error bars: ±SEM, n=3. Significant differences relative to DMSO control are represented as * P≤0.05, ** P≤0.01, *** P≤0.001.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Angew. Chem. Int. Ed. Engl.