ZFIN Image: Chang et al., 2025, Figure 6

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Figure 6

The underlying mechanism of apoptosis and G2/M arrest was determined by ROS assay and ELISA. The apoptotic cell-induced effects of helenalin, BHM, and BHG were detected by increasing ROS levels (a) and p53 expression (b). Helenalin, BHM, and BHG suppressed STAT3-MYC-CDC25-CDK1 signaling and increased p21 to induce G2/M arrest in MDA-MB-231 cells (c–f). * represented p < 0.05 as compared to untreated control. Each data is expressed as the mean ± standard error of at least two experiments, each performed in duplicate.

Acknowledgments

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