ZFIN Image: Constanty et al., 2025, Fig. 10

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Figure Caption

Fig. 10 Working model and summary of our study.

A Working model of CM invasion to replace injured tissue during zebrafish heart regeneration. CM-intrinsic mechanisms, partly regulated by AP-1 transcription factors, promote actin cytoskeletal remodeling/organization and protrusion formation, while Mmp14b and macrophages contribute to remodeling the ECM at the border zone to create a permissive environment for CM invasion. Created in BioRender. Beisaw, A. (2025) https://BioRender.com/19dzxy0. B Summary of the genetic models presented in our study and their effects on CM protrusion and invasion, including CM:A-Fos to block AP-1, mmp14b deletion, CM:mmp14b OE, and CM:mmp14b OE in the absence of macrophages. The effects of mmp14b deletion on endothelial cells (blood vessels) in the model is from previously published data⁶⁸. BZ border zone, CM cardiomyocyte, ECM extracellular matrix, Fb fibroblast, mϕ macrophage, OE overexpression.

Acknowledgments

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