Fig. 5

Fig. 5

Correlation and clinical impact of KDM4C and GATA1 expression in HNSCC. A Representative immunohistochemical staining for KDM4C and GATA1 in tumor slides from HNSCC patients. Scale bar = 50 μm. B, C Distribution of KDM4C and GATA1 staining intensity across different pStage groups. D Spearman’s correlation analysis of KDM4C and GATA1 expression with clinical stages in HNSCC (pT: primary tumor extent, pN: regional lymph node metastasis, pM: distant metastasis). E‒G Kaplan-Meier survival curves demonstrating the association of high expression of KDM4C (E), GATA1 (F), and both (G) with reduced overall survival in HNSCC patients. Grouping is based on H-score averages for high/low expression. H Pearson correlation analysis between KDM4C expression and GATA1 levels in 85 HNSCC cases. I Chi-square test assessing the statistical significance of the correlation between KDM4C and GATA1. J Receiver operating characteristic (ROC) curve analysis evaluating the diagnostic potential of KDM4C and GATA1 in HNSCC. P-values are determined by a two-tailed Student’s t-test for group comparisons (A, B). *P < 0.05, **P < 0.01, ***P < 0.001, ns not significant