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Fig. 6 Differentially methylated genes following 48 h TO exposure in HepG2 cells. (A) A total of 1488 overlapping differentially methylated genes were found with p < 0.05 and |log2(fold change)| >0.263. (B) Volcano plot analysis, (C) KEGG enrichment, and (D) GO enrichment were performed on the differentially methylated genes between the CON and TO groups. (E) The heat map shows the differentially methylated genes related to DNA replication, cell cycle, lysosome, cellular senescence, and metabolic pathway in the CON and TO groups. GSEA analysis highlights specific trends in (F) DNA replication, (G) cell cycle, and (H) lysosome following TO treatment.
Reprinted from Phytomedicine : international journal of phytotherapy and phytopharmacology, 140, Lin, Y., Zhang, J., Gao, X., Wu, Z., Yang, L., Tian, K., Lv, X., Li, J., Chen, K., Zhang, Y., Hu, H., Zhu, A., Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade, 156586156586, Copyright (2025) with permission from Elsevier. Full text @ Phytomedicine