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Fig. 5 Transcriptome-wide analysis of m6A modifications following 48 h TO exposure in HepG2 cells. (A) MTT assay results demonstrate the relative cell viability following 48 h of TO treatment. (B) Cell LDH leakage levels after TO treatment for 48 h, n = 3, ***p < 0.001. (C) PCA analysis was conducted to demonstrate differentiation between the CON and TO groups. (D) The overlap of m6A genes among CON, TO and L-02 cell groups. (E) The m6A peaks in CON and TO groups. (F) The m6A consensus motif for RRACH. (G) The number of m6A methylation peaks, and (H) the m6A modification peaks' density within mRNA transcripts. (I) The effect of m6A peaks and m6A genes on disease after treatment with TO.
Reprinted from Phytomedicine : international journal of phytotherapy and phytopharmacology, 140, Lin, Y., Zhang, J., Gao, X., Wu, Z., Yang, L., Tian, K., Lv, X., Li, J., Chen, K., Zhang, Y., Hu, H., Zhu, A., Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade, 156586156586, Copyright (2025) with permission from Elsevier. Full text @ Phytomedicine