ZFIN Image: Minoia et al., 2025, Figure 3

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Figure 3

Effects of homotaurine on osteogenesis and angiogenesis gene expression in zebrafish. (A) In zebrafish larvae treated for 14 days, homotaurine significantly increased the expressions of the ctnnb1, runx2b, and sp7 genes, crucial for skeletal formation. (B) Similar effects on the skeletal gene expression levels of ctnnb1, runx2b, runx2b, and sp7 were observed in 4-month-old zebrafish. (C,D) In aged zebrafish (36 months old) treated with homotaurine for 7 days, (C) vascular endothelial growth factor receptor 2 (VEGFR2) expression was notably enhanced, (D) particularly in the tail region, as visualized in the kinase insert domain receptor-like–enhanced green fluorescent protein (KDRL-EGFP) transgenic model. Magnifications 4x (C) and 10x (D); (* p < 0.05; ** p < 0.01; *** p < 0.005).

Acknowledgments

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