ZFIN Image: Wu et al., 2025, FIGURE 3

Image

Figure Caption

FIGURE 3

SB218078 inhibits angiogenesis in vivo. (A) Representative images showing the sprouting of vascular endothelial cells in different groups treated with vehicle control and SB218078 (1 μM and 2 μM) in the rat arterial ring assay. (B) Quantification of the relative overall length of endothelial cell sprouting induced by SB218078 in each treatment group. (C) Representative images of the Matrigel plug assay in mice treated with vehicle control (DMSO) and SB218078 (2 μM). (D, E) Immunofluorescence staining for CD31, along with statistical analysis of microvessel density. (F, G) Kinase assays conducted to identify potential targets of SB218078 for its anti-angiogenic effects. Scale bar in (A, D): 50 μm.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Front Pharmacol