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Figure 2
Bone Remodeling: Hormonal regulation of signaling pathways and molecules involved. Bone resorption: Receptor Activator of Nuclear factor Kappa beta Ligand (RANKL) calcitonin and TGF-β are involved in the activation of osteoclasts, promoting bone resorption. Reversal: Resorption is followed by a reversal process where TGF-β, IGF1, 2, BMPs, and FGFs play a central role and activate osteocytes. Bone formation: After activation, osteocytes lead to bone formation involving molecules including
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