ZFIN Image: Mehreen et al., 2025, Figure 1

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Figure 1

Events followed during Axolotl’s Limb Regeneration. (1) Amputation plane where limbs can be amputated to witness the events leading to regeneration. (2) Formation of wound epidermis followed by initial immune response for clearing the pathogens and unwanted mass. (3) Nerve formation is essential for blastema formation and growth. (4) Blastema is the mass of de-differentiated cells necessary for regeneration. (5) Blastema cells proliferate and differentiate into cells of choice to develop into new limbs, looking like the original ones. (6) Patterning of limbs starts that gives rise to new limbs just like the original ones.

Acknowledgments

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